Welcome to the Laboratory of Chromosome Dynamics and Gene Regulation at the Indian Institute of Technology, Hyderabad, India. We aim to understand the mechanism of cell division/chromosome segregation and gene regulation using cutting-edge single-molecule imaging, fluorescence microscopy, genomics, proteomics, cell and molecular biology and yeast genetics. Our broad research interest lies in studying the functions of chromatin remodelers during meiotic chromosome segregation, understanding the single-molecule dynamics of the mitotic kinases such as aurora kinases, cyclin-dependent kinase 1, polo kinases, checkpoint regulators etc. during mitosis, exploring the mechanism of epigenetic transcription memory/mitotic bookmarking and understanding how the mitotic to meiotic transition is achieved at the level of 3D genome organization, kinetochore composition and transcriptome. Our basic science research efforts are geared towards developing therapeutics to treat infertility, genetic disorders and cancers.

About PI

Hello, I am an enthusiastic cell biology researcher with extensive training in single-molecule imaging and fluorescence microscopy with a keen interest in studying chromosome biology and transcription. I earned a Ph.D. from IIT Bombay, India (2015) where I explored the molecular mechanism of meiotic chromosome segregation, a process by which sperms and eggs are produced in humans. I developed imaging and biochemical approaches to quantify chromosome missegregation during meiosis and my research provides an avenue for therapeutic development to treat genetic disorders, infertility and cancers. In 2015, I was offered a post-doctoral position at the National Cancer Institute, National Institutes of Health, MD, USA where I developed Single-Molecule Imaging technology to quantify the dynamics of proteins in live cells at the single-molecule level. Using this method, I revealed the dynamics of transcription factor binding and chromatin remodeling at a specific gene promoter. In 2020, I joined IIT Hyderabad as a Principal Investigator/Assistant Professor, where I aim to establish research and teaching programs focusing on Single-Molecule Biophysics to understand chromosome biology and gene regulation with a broad emphasis on infertility, developmental disorders and cancers.

Dr. Gunjan Mehta, Ph.D.

Principal Investigator/

Assistant Professor

 

ORCID iD: 0000-0003-2896-3039

SCOPUS ID: 36437518800

publons ID: 1275259

Loop ID: 713661

Vidwan ID: 193688

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EDUCATION

RESEARCH INTERESTS

Cell Division and Chromosome Dynamics

2009 - 2015

Indian Institute of Technology Bombay, Mumbai, India

Ph.D. Biosciences and Bioengineering

Transcription Regulation

Single-Molecule Imaging

Developmental Disorders and Cancers

2007 - 2009

The M.S. University of Baroda, Vadodara, India

M.Sc. Microbiology

2003 - 2006

St. Xavier's College, Ahmedabad, India

B.Sc. Biochemistry and Biotechnology

Epigenetic Transcription Memory/Mitotic Bookmarking

POST-DOCTORAL RESEARCH

2015- 2020

National Cancer Institute,

National Institutes of Health, Bethesda, MD, USA

Single-Molecule Imaging and Transcription Regulation

Mitotic Kinases and Chromatin Remodelers

Indian Institute of Technology Hyderabad, India

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