
Laboratory of Chromosome Dynamics and Gene Regulation
Principal Investigator
Dr. Gunjan Mehta, Ph.D.
- Claude Bernard -
“The joy of discovery is certainly the liveliest that the mind of man can ever feel”
PUBLICATIONS

25) Banerjee S, Purva, Dodamani A, Kumari A, Singha S, Varde O, Mehta G, Nambiar M. Meiotic cohesin paralogs govern cell survival by exhibiting flexibility in partner choice. bioRxiv 2026 (https://www.biorxiv.org/content/10.64898/2026.03.27.714714v1)
24) Paliwal S, Dey P, Kumari A, Sadasivam K, Joshi S, Raghuvanshi R, Goyal R, Sanyal K, Nishant KT, Shinohara A, Mehta G*. The dynamic pool of Rec8-cohesin is crucial for meiotic recombination and transcription in the yeast S. cerevisiae. Journal of Biological Chemistry 2026 (Accepted)
23) Ettikuppam A, Podh N, Tuti NK, Mehta G, Roy A, Rath SN. Co-expression of superoxide and peroxide scavenging antioxidant enzymes rescues β cells from hypoxia and hyperglycemia-induced oxidative damage. Tissue Cell 2026; 101:103424. (https://pubmed.ncbi.nlm.nih.gov/41806631/)
22) Mann R, Soota D, Das A, Podh NK, Mehta G, Notani D*. Paused RNA polymerase primes promoters via RNA-mediated stabilisation of transcription factor ERα. Nature Communications 2025;16(1):9553 (https://pubmed.ncbi.nlm.nih.gov/41162393/)
21) Podh NK, Das A, Kumari A, Garg K, Yadav R, Kashyap K, Islam S, Gupta A, Mehta G*. Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in S. cerevisiae. Life Science Alliance 2025; 8(7),e202503290. (https://pubmed.ncbi.nlm.nih.gov/40250989/)
20) Reza MH, Aggarwal R, Verma J, Podh NK, Chowdhury R, Mehta G, Manjithaya R, Sanyal K*. Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation. PLoS Biology 2025; 23(4):e3003069. (https://pubmed.ncbi.nlm.nih.gov/40173187/)
19) Kumari A, Podh NK, Sen S, Kashyap K, Islam S, Rajakumara E, Gupta, A, Nambiar M, Mehta G*. Single-Molecule Tracking dataset for histone H3 (hht1) from live and fixed cells of Schizosaccharomyces pombe. Nature Scientific Data 2024;11:1393. (https://pubmed.ncbi.nlm.nih.gov/39695245/)
18) Paliwal S#, Dey P#, Tambat S, Shinohara A, Mehta G*. Role of ATP-dependent chromatin remodelers in meiosis. Trends in Genetics (Cell Press) 2024;41(3):236-250.
https://pubmed.ncbi.nlm.nih.gov/39550320/
17) Kinger S, Jagtap YA, Kumar P, Choudhary A, Prasad A, Prajapati VK, Kumar A, Mehta G, Mishra A*. Proteostasis in neurodegerative diseases. Advances in Clinical Chemistry 2024;121:270-333.
https://www.sciencedirect.com/science/article/abs/pii/S0065242324000635
16) Podh NK#, Das A#, Dey P, Paliwal S, Mehta G*. Single-Molecule Tracking Dataset of Histone H3 (Hht1) in Saccharomyces cerevisiae. Data in Brief 2023;47:108925.
https://pubmed.ncbi.nlm.nih.gov/36798603/
15) Podh NK#, Das A#, Dey P, Paliwal S, Mehta G*. Single-Molecule Tracking for studying protein dynamics and target-search mechanism in live cells of S. cerevisiae. STAR Protocols (Cell Press) 2022; 3(4): 101900.
https://pubmed.ncbi.nlm.nih.gov/36595957/
14) Mehta G*, Sanyal K, Suman A, Eerappa R, Ghosh SK*. Minichromosome Maintenance Proteins in Eukaryotic Chromosome Segregation. BioEssays 2022; 44(1): 0265-9247.
https://pubmed.ncbi.nlm.nih.gov/34841543/
13) Podh NK, Paliwal S, Dey P, Das A, Morjaria S, Mehta GD*. In-vivo Single-Molecule Imaging in Yeast: Applications and Challenges. Journal of Molecular Biology 2021; 433(22):167250.
https://pubmed.ncbi.nlm.nih.gov/34537238/
12) Mehta GD, Ball DA, Eriksson PR, Chereji RV, Clark DJ, McNally JG, Karpova TS. Single-Molecule analysis reveals linked cycles of RSC chromatin remodeling and Ace1 transcription factor binding in yeast. Molecular Cell 2018; 72:875-887.
https://pubmed.ncbi.nlm.nih.gov/30318444/
11) Mehta GD, Anbalagan GK, Singh AP, Gadre P, Ghosh SK. An interplay between Shugoshin and Spo13 for centromeric cohesin protection and sister kinetochore monoorientation during meiosis I in Saccharomyces cerevisiae. Current Genetics 2018; 64:1141-1152.
https://pubmed.ncbi.nlm.nih.gov/29644457/
10) Ball D#, Mehta GD#, Salomon-Kent R, Mazza D, Morisaki T, Mueller F, McNally JG, Karpova T. Single-molecule tracking of Ace1p in Saccharomyces cerevisiae defines a characteristic residence time for non-specific interactions of transcription factors with chromatin. Nucleic Acids Research 2016; 44(21);e160.
https://pubmed.ncbi.nlm.nih.gov/27566148/
9) Agarwal M, Mehta GD, Ghosh SK. Role of Ctf3 and COMA subcomplexes in meiosis: implication in maintaining Cse4 at the centromere and numeric spindle poles. Biochimica Biophysica Acta-Molecular Cell Research 2015; 1853(3);671-684.
https://pubmed.ncbi.nlm.nih.gov/25562757/
8) Mehta GD, Agarwal M, Ghosh SK. Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae. Molecular Microbiology 2014; 91(6):1179-1199.
https://pubmed.ncbi.nlm.nih.gov/24446862/
7) Mehta GD, Kumar R, Srivastava S, Ghosh SK. Cohesin: Functions beyond sister chromatid cohesion. FEBS Letters 2013; 587(15): 2299-2312.
https://pubmed.ncbi.nlm.nih.gov/23831059/
6) Das A, Kapoor A, Mehta GD, Ghosh SK, Sen S. Extracellular Matrix Density Regulates Extracellular Proteolysis via Modulation of Cellular Contractility. Journal of Carcinogenesis and Mutagenesis 2013; S13:003. doi: 10.4172/2157-2518.S13-003.
5) Lahiri S, Mehta GD and Ghosh SK. Iml3p, a component of the Ctf19 complex of the budding yeast kinetochore is required to maintain kinetochore integrity under conditions of spindle stress. FEMS Yeast Research 2013; 13(4): 375-385.
https://pubmed.ncbi.nlm.nih.gov/23480593/
4) Mehta GD, Rizvi SM and Ghosh SK. Cohesin: a guardian of genome integrity. Biochimica Biophysica Acta-Molecular Cell Research 2012; 1823(8): 1324-1342.
https://pubmed.ncbi.nlm.nih.gov/22677545/
3) Mehta GD, Agarwal M and Ghosh S. Centromere Identity: A challenge to be faced. Molecular Genetics and Genomics 2010; 284(2): 75-94.
https://pubmed.ncbi.nlm.nih.gov/20585957/
2) Ray S, Mehta GD and Srivastava S. Label-free detection techniques for protein microarrays: prospects, merits and challenges. Proteomics 2010; 10: 731-748.
https://pubmed.ncbi.nlm.nih.gov/19953541/
1) Singh AK, Mehta GD and Chhatpar HS. Optimization of medium constituents for improved chitinase production by Paenibacillus sp. D1 using statistical approach. Letters in Applied Microbiology 2009; 49: 708-714.
https://www.ncbi.nlm.nih.gov/pubmed/19780958
* Corresponding Author
# Co-first author
